Surveillance for Barrett's oesophagus
نویسندگان
چکیده
منابع مشابه
Whole genome methylation analysis of non-dysplastic Barretts oesophagus that progresses to invasive cancer
Objective: To investigate differences in methylation between patients with nondysplastic Barretts’ oesophagus who progress to invasive adenocarcinoma and those that do not. Design: A whole genome methylation interrogation using the Illumina HumanMethylation 450 array of patients with non-dysplastic Barrett’s Oesophagus who either develop adenocarcinoma or remain static, with validation of findi...
متن کاملSurveillance in Barrett's oesophagus: a personal view.
Barrett's oesophagus is defined as columnar-lined oesophagus of any length containing specialised intestinal metaplasia. Diagnosis depends on close corroboration between the endoscopist and histopathologist. It occurs in 10% of patients presenting endoscopically with reflux symptoms and has an adenocarcinoma incidence of 0.4% to 2%. Surveillance is performed to detect precancerous change (dyspl...
متن کاملAre screening and surveillance for Barrett's oesophagus really worthwhile?
Oesophageal adenocarcinoma has a low incidence and still remains an uncommon cancer; however, it has been on the rise over the past 20 years. Barrett's oesophagus, a complication of gastro-oesophageal reflux disease, is the only known precursor of this adenocarcinoma. It can often be asymptomatic and probably goes undiagnosed in the majority of the population. There are no direct data supportin...
متن کاملCost-effectiveness of Barrett's oesophagus screening and surveillance.
Endoscopic screening and surveillance of patients with Barrett's oesophagus to detect oesophageal cancer at earlier stages is contentious. As a consequence, their cost-effectiveness is also debatable. Current health economic evidence shows mixed results for demonstrating their value, mainly due to varied assumptions around progression rates to cancer, quality of life and treatment pathways. No ...
متن کاملNew developments in the endoscopic surveillance of Barrett's oesophagus.
Patients with a Barrett's oesophagus are at risk for developing an adenocarcinoma of the distal oesophagus. Therefore, many patients undergo endoscopic surveillance to detect dysplasia and/or cancer at an early and curable stage. However, early neoplastic lesions are difficult to identify with standard endoscopy. In addition, the low incidence of these lesions, currently estimated at 0.5% per y...
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ژورنال
عنوان ژورنال: BMJ
سال: 2001
ISSN: 0959-8138
DOI: 10.1136/bmj.322.7294.1124